What Is Epitalon?
Epitalon (also written Epithalon) is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly. It was developed in Russia by Professor Vladimir Khavinson and colleagues at the Institute of Bioregulation and Gerontology in St. Petersburg, based on the natural peptide complex Epithalamin isolated from the bovine pineal gland. Epitalon has been the subject of a significant body of peer-reviewed research, particularly in Russian scientific literature, covering areas ranging from telomere biology to circadian rhythm regulation.
Research Areas
Telomerase Activation: Epitalon has been studied for its ability to activate telomerase, the enzyme responsible for extending telomere length in chromosomes. Telomere shortening is associated with cellular senescence and ageing. Several in vitro studies have reported that Epitalon activates telomerase and may extend cellular lifespan in culture models.
Pineal Gland and Melatonin Regulation: As a peptide derived from the pineal gland, Epitalon has been researched for its effects on pineal function, melatonin secretion, and circadian rhythm regulation. Research models suggest it may normalise age-related decline in melatonin production.
Antioxidant Activity: Several studies have reported antioxidant properties for Epitalon, suggesting a potential role in reducing oxidative stress markers in aged tissues.
Gene Expression and Longevity: Epitalon has been studied in animal models for effects on gene expression related to ageing, immune function, and tumour suppression. Some long-term animal studies reported extended lifespan in rodent models treated with Epitalon.
Storage and Reconstitution
Epitalon is a short tetrapeptide and is relatively stable compared to larger molecules. Store lyophilised vials at -20°C for long-term use or at 2–8°C for short-term storage up to 6 months. Reconstitute with bacteriostatic water according to standard protocols. The reconstituted solution is stable at 2–8°C for 4–6 weeks.
Sourceing Epitalon in Europe
Peptifly supplies Epitalon in 10mg lyophilised vials, independently tested for 99%+ purity, dispatched from EU warehouses with cold-chain packaging. Browse at peptifly.com/shop.
Frequently Asked Questions
What is Epitalon used for in research?
Epitalon is primarily researched in the context of ageing biology, telomere dynamics, pineal function, and longevity. It has been the subject of substantial peer-reviewed research, primarily from Russian and Ukrainian institutions.
How does Epitalon relate to telomerase?
In vitro studies have reported that Epitalon activates telomerase, an enzyme that extends telomere length. Telomere maintenance is of significant interest in ageing research.
Where can I buy Epitalon in Europe?
Peptifly supplies Epitalon 10mg vials with EU dispatch and independent purity verification. Order at peptifly.com/shop.
Disclaimer: All peptides sold by Peptifly are strictly for research and laboratory use only. This article is for informational purposes only.